Protein Function Prediction using Phylogenomics, Domain Architecture Analysis, Data Integration, and Lexical Scoring
نویسنده
چکیده
منابع مشابه
Phylogenomic inference of protein molecular function: advances and challenges
MOTIVATION Protein families evolve a multiplicity of functions through gene duplication, speciation and other processes. As a number of studies have shown, standard methods of protein function prediction produce systematic errors on these data. Phylogenomic analysis--combining phylogenetic tree construction, integration of experimental data and differentiation of orthologs and paralogs--has bee...
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Phylogenomic analysis addresses the limitations of function prediction based on annotation transfer, and has been shown to enable the highest accuracy in prediction of protein molecular function. The Berkeley Phylogenomics Group provides a series of web servers for phylogenomic analysis: classification of sequences to pre-computed families and subfamilies using the PhyloFacts Phylogenomic Encyc...
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Structural phylogenomics refers to the combined use of evolutionary and structural information in a bioinformatics analysis. The term phylogenomics refers to two distinct tasks: reconstructing a species phylogeny using multiple genes (for a review, see [1]) and predicting protein function by estimating the evolutionary history of a family of related sequences (i.e., a gene tree or multi-gene tr...
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